Publications
My research interests lie in developing novel, preclinical immunotherapies for glioblastoma (GBM) and translating these therapies for the clinic. Much of my research has been focused on developing next generation chimeric antigen receptor (CAR) T cell therapies to treat brain tumors. I am deeply interested in how therapies like CARs can be leveraged to combat the highly immunosuppressive tumor microenvironment. Additionally, CARs can also be used to resolve the issue of heterogeneity in solid tumors. Heterogeneity remains a roadblock to successful treatment of GBM, but I believe my research can shine some light on potential solutions.
Updated: 2021 April 14
"CAR T cells and checkpoint inhibition for the treatment of glioblastoma"
Shen SH, Woroniecka K, Barbour AB, Fecci PE, Sanchez-Perez L, Sampson JH. CAR T cells and checkpoint inhibition for the treatment of glioblastoma. Expert Opin Biol Ther. 2020 Jun;20(6):579-591. doi: 10.1080/14712598.2020.1727436. Epub 2020 Feb 17. PMID: 32027536; PMCID: PMC7202971.
"Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease"
Kemeny HR, Elsamadicy AA, Farber SH, Champion CD, Lorrey SJ, Chongsathidkiet P, Woroniecka KI, Cui X, Shen SH, Rhodin KE, Tsvankin V, Everitt J, Sanchez-Perez L, Healy P, McLendon RE, Codd PJ, Dunn IF, Fecci PE. Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease. Clin Cancer Res. 2020 Mar 1;26(5):1141-1151. doi: 10.1158/1078-0432.CCR-18-3486. Epub 2019 Nov 19. PMID: 31744830.
"Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts"
Suryadevara CM, Desai R, Farber SH, Choi BD, Swartz AM, Shen SH, Gedeon PC, Snyder DJ, Herndon JE 2nd, Healy P, Reap EA, Archer GE, Fecci PE, Sampson JH, Sanchez-Perez L. Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts. Clin Cancer Res. 2019 Jan 1;25(1):358-368. doi: 10.1158/1078-0432.CCR-18-1211. Epub 2018 Nov 13. PMID: 30425092; PMCID: PMC6390292.
"Promising vaccines for treating glioblastoma"
Swartz AM, Shen SH, Salgado MA, Congdon KL, Sanchez-Perez L. Promising vaccines for treating glioblastoma. Expert Opin Biol Ther. 2018 Nov;18(11):1159-1170. doi: 10.1080/14712598.2018.1531846. Epub 2018 Oct 15. PMID: 30281978.
"A new class of synthetic retinoid antibiotics effective against bacterial persisters"
Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E. A new class of synthetic retinoid antibiotics effective against bacterial persisters. Nature. 2018 Apr 5;556(7699):103-107. doi: 10.1038/nature26157. Epub 2018 Mar 28. PMID: 29590091; PMCID: PMC6462414.
"Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma"
Suryadevara CM, Desai R, Abel ML, Riccione KA, Batich KA, Shen SH, Chongsathidkiet P, Gedeon PC, Elsamadicy AA, Snyder DJ, Herndon JE 2nd, Healy P, Archer GE, Choi BD, Fecci PE, Sampson JH, Sanchez-Perez L. Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma. Oncoimmunology. 2018 Feb 21;7(6):e1434464. doi: 10.1080/2162402X.2018.1434464. PMID: 29872570; PMCID: PMC5980382.
"Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin"
Johnston T, Hendricks GL, Shen S, Chen RF, Kwon B, Kelso MJ, Kim W, Burgwyn Fuchs B, Mylonakis E. Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin. Future Med Chem. 2016 Oct;8(16):1941-1952. doi: 10.4155/fmc-2016-0104. Epub 2016 Sep 21. PMID: 27652456; PMCID: PMC5619112.
"Fibroblast growth factor 15 deficiency impairs liver regeneration in mice"
Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, Aleksunes LM, Richardson JR, Apte U, Rudnick DA, Guo GL. Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G893- 902. doi: 10.1152/ajpgi.00337.2013. Epub 2014 Apr 3. PMID: 24699334; PMCID: PMC4024724.